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Article

Nuclear localization of Tob is important for regulation of its antiproliferative activity.

Oncogene - 26 Aug 2004

Kawamura-Tsuzuku Junko, Suzuki Toru, Yoshida Yutaka, Yamamoto Tadashi

Abstract excerpt

TOB: is a member of an antiproliferative gene family that includes btg1, pc3/tis21/btg2, pc3b, ana/btg3, and tob2. Exogenous overexpression of the family proteins suppresses cell proliferation. These proteins participate in transcriptional regulation of several genes. Here, we show that Tob is a nuclear protein that is imported into the nucleus through a nuclear localization signal (NLS)-mediated mechanism....

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PMID: 15235587
DOI: 10.1038/sj.onc.1207890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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