Article
Mice lacking a transcriptional corepressor Tob are predisposed to cancer.
Genes & development - 15 May 2003
Yoshida Yutaka, Nakamura Takahisa, Komoda Masato, Satoh Hitoshi, Suzuki Toru, Tsuzuku Junko K, Miyasaka Takashi, Yoshida Eri H, Umemori Hisashi, Kunisaki Reiko K, Tani Kenzaburo, Ishii Shunsuke, Mori Shigeo, Suganuma Masami, Noda Tetsuo, Yamamoto Tadashi
Abstract excerpt
tob is a member of antiproliferative family genes. Mice lacking tob are prone to spontaneous formation of tumors. The occurrence rate of diethylnitrosamine-induced liver tumors is higher in tob(-/-) mice than in wild-type mice. tob(-/-)p53(-/-) mice show accelerated tumor formation in comparison with single null mice. Expression of cyclin D1 mRNA is increased in the absence of Tob and is reduced by Tob. Tob acts...
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