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Article

Tob proteins suppress steroid hormone receptor-mediated transcriptional activation.

Molecular and cellular endocrinology - 31 Jan 2005

Kawate Hisaya, Wu Yin, Ohnaka Keizo, Nawata Hajime, Takayanagi Ryoichi

Abstract excerpt

Although sex steroid hormones have significant effects on bone metabolism, the molecular mechanisms of these actions have not been fully elucidated yet. We examined the functional relationship between steroid hormone receptors and Tob, a member of an anti-proliferative protein family and a negati...

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Source

Identifiers

PMID: 15664454
DOI: 10.1016/j.mce.2004.10.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15664454-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

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Tob proteins suppress steroid hormone receptor-mediated transcriptional activation.PMID 15664454Read ↗

Negative regulation of BMP/Smad signaling by Tob in osteoblasts.Semantic proximity Read ↗

Nuclear localization of Tob is important for regulation of its antiproliferative activity.Semantic proximity Read ↗

The Anti-Proliferative Activity of BTG/TOB Proteins Is Mediated via the Caf1a (CNOT7) and Caf1b (CNOT8) Deadenylase Subunits of the Ccr4-Not ComplexSemantic proximity Read ↗

Whole genome microarray analysis of growth hormone-induced gene expression in bone: T-box3, a novel transcription factor, regulates osteoblast proliferationSemantic proximity Read ↗

Mice lacking a transcriptional corepressor Tob are predisposed to cancer.Semantic proximity Read ↗

Physical and Functional Interactions between STAT5 and Runx Transcription FactorsSemantic proximity Read ↗

BTG2 is an LXXLL-dependent co-repressor for androgen receptor transcriptional activity.Semantic proximity Read ↗

Repression of Runx2 by Androgen Receptor (AR) in Osteoblasts and Prostate Cancer Cells: AR Binds Runx2 and Abrogates Its Recruitment to DNASemantic proximity Read ↗

Triiodothyronine, a regulator of osteoblastic differentiation: depression of histone H4, attenuation of c-fos/c-jun, and induction of osteocalcin expression.Semantic proximity Read ↗

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