Article
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Cell - 16 Apr 2004
Sabatier Christelle, Plump Andrew S, Le Ma, Brose Katja, Tamada Atsushi, Murakami Fujio, Lee Eva Y-H P, Tessier-Lavigne Marc
Abstract excerpt
Commissural axons in vertebrates and insects are initially attracted to the nervous system midline, but once they reach this intermediate target they undergo a dramatic switch, becoming responsive to repellent Slit proteins at the midline, which expel them onto the next leg of their trajectory. We have unexpectedly implicated a divergent member of the Robo family, Rig-1 (or Robo3), in preventing premature Slit...
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