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Article

The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.

Cell - 16 Apr 2004

Sabatier Christelle, Plump Andrew S, Le Ma, Brose Katja, Tamada Atsushi, Murakami Fujio, Lee Eva Y-H P, Tessier-Lavigne Marc

Abstract excerpt

Commissural axons in vertebrates and insects are initially attracted to the nervous system midline, but once they reach this intermediate target they undergo a dramatic switch, becoming responsive to repellent Slit proteins at the midline, which expel them onto the next leg of their trajectory. W...

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Identifiers

PMID: 15084255
DOI: 10.1016/s0092-8674(04)00303-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15084255-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.PMID 15084255Read ↗

The slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons.Semantic proximity Read ↗

Crossing the midline: roles and regulation of Robo receptors.Semantic proximity Read ↗

Alternative splicing of the Robo3 axon guidance receptor governs the midline switch from attraction to repulsion.Semantic proximity Read ↗

Commissureless is required both in commissural neurones and midline cells for axon guidance across the midline.Semantic proximity Read ↗

In Vivo Functional Analysis of Drosophila Robo1 Fibronectin Type-III Repeats.Semantic proximity Read ↗

Midline crossing and Slit responsiveness of commissural axons require USP33.Semantic proximity Read ↗

Short-range and long-range guidance by Slit and its Robo receptors: a combinatorial code of Robo receptors controls lateral position.Semantic proximity Read ↗

Axon guidance at the midline choice point.Semantic proximity Read ↗

Independent functions of Slit-Robo repulsion and Netrin-Frazzled attraction regulate axon crossing at the midline in Drosophila.Semantic proximity Read ↗

Dosage-sensitive and complementary functions of roundabout and commissureless control axon crossing of the CNS midline.Semantic proximity Read ↗

Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis.Semantic proximity Read ↗

RETRACTED: Hierarchical organization of guidance receptors: silencing of netrin attraction by slit through a Robo/DCC receptor complex.Semantic proximity Read ↗

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