Article
False positive rates in association studies as a function of degree of stratification.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2004
Koller Daniel L, Peacock Munro, Lai Dongbing, Foroud Tatiana, Econs Michael J
Abstract excerpt
UNLABELLED: To explore the degree to which stratification can cause spurious positive association results, we tested for association between BMD and 373 genetic markers using 381 white and 126 black females. The rate of positive results doubled as the proportion of stratification increased, showing the importance of controlling for stratification in association studies. INTRODUCTION: Population-based association...
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