Article
Demonstrating stratification in a European American population.
Nature genetics - 1 Aug 2005
Campbell Catarina D, Ogburn Elizabeth L, Lunetta Kathryn L, Lyon Helen N, Freedman Matthew L, Groop Leif C, Altshuler David, Ardlie Kristin G, Hirschhorn Joel N
Abstract excerpt
Population stratification occurs in case-control association studies when allele frequencies differ between cases and controls because of ancestry. Stratification may lead to false positive associations, although this issue remains controversial. Empirical studies have found little evidence of stratification in European-derived populations, but potentially significant levels of stratification could not be ruled...
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