Impaired mitochondrial Ca2+ homeostasis in respiratory chain-deficient cells but efficient compensation of energetic disadvantage by enhanced anaerobic glycolysis due to low ATP steady state levels.

doi:10.1016/j.yexcr.2007.04.015

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Article

Impaired mitochondrial Ca2+ homeostasis in respiratory chain-deficient cells but efficient compensation of energetic disadvantage by enhanced anaerobic glycolysis due to low ATP steady state levels.

Experimental cell research - 15 Aug 2007

von Kleist-Retzow Jürgen-Christoph, Hornig-Do Hue-Tran, Schauen Matthias, Eckertz Sabrina, Dinh Tuan Anh Duong, Stassen Frank, Lottmann Nadine, Bust Maria, Galunska Bistra, Wielckens Klaus, Hein Wolfgang, Beuth Joseph, Braun Jan-Matthias, Fischer Jürgen H, Ganitkevich Vladimir Y, Maniura-Weber Katharina, Wiesner Rudolf J

Abstract excerpt

Energy-producing pathways, adenine nucleotide levels, oxidative stress response and Ca(2+) homeostasis were investigated in cybrid cells incorporating two pathogenic mitochondrial DNA point mutations, 3243A>G and 3302A>G in tRNA(Leu(UUR)), as well as Rho(0) cells and compared to their parental 143B osteosarcoma cell line. All cells suffering from a severe respiratory chain deficiency were able to proliferate as...

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PMID: 17509565
DOI: 10.1016/j.yexcr.2007.04.015

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