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Article

Cells bearing mutations causing Leber's hereditary optic neuropathy are sensitized to Fas-Induced apoptosis.

The Journal of biological chemistry - 22 Feb 2002

Danielson Steven R, Wong Alice, Carelli Valerio, Martinuzzi Andrea, Schapira Anthony H V, Cortopassi Gino A

Abstract excerpt

Three prevalent mitochondrial DNA pathogenic mutations at positions 11778, 3460, and 14484, which affect different subunits of Complex I, cause retinal ganglion cell death and optic nerve atrophy in Leber's hereditary optic neuropathy (LHON). The cell death is painless and without inflammation, c...

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Identifiers

PMID: 11741983
DOI: 10.1074/jbc.M110119200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11741983-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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