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Article

Effect of the overexpression of mutant ubiquitin (K48R) on the cellular response induced by 4-hydroxy-2,3-trans-nonenal, an end-product of lipid peroxidation.

Neuroscience letters - 25 Jun 2010

Hyun Dong-Hoon

Abstract excerpt

Impairment of the ubiquitin-proteasome system (UPS) for degrading abnormal proteins leads to protein aggregates and increased protein oxidation/nitration. This study was performed to show that interference with polyubiquitination in the presence of 4-hydroxy-2,3-trans-nonenal (HNE) has similar consequences. Levels of polyubiquitin chains were not increased in NT-2 and SK-N-MC cells overexpressing a...

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PMID: 20433899
DOI: 10.1016/j.neulet.2010.04.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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