Article
Sensitivity of mammalian cells expressing mutant ubiquitin to protein-damaging agents.
The Journal of biological chemistry - 7 Dec 2001
Tsirigotis M, Zhang M, Chiu R K, Wouters B G, Gray D A
Abstract excerpt
There is convincing evidence from studies in yeast that a functional ubiquitin/proteasome pathway is required to degrade misfolded or oxidatively damaged proteins but for technical reasons, it has been difficult to perform comparable studies in mammalian cells. To investigate the possibility that the ubiquitin/proteasome pathway is cytoprotective for mammalian cells, we have introduced epitope-tagged wild-type...
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