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Large MAF Transcription Factors Reawaken Evolutionarily Dormant Fast-Glycolytic Type IIb Myofibers in Human Skeletal Muscle

2024-12-11

Abstract excerpt

Small mammals rely on type IIb myofibers, expressing the fastest myosin IIb (encoded by MYH4 ), for rapid muscle contraction. In contrast, larger mammals, including humans, show reduced or absent MYH4 expression and type IIb myofibers, favoring slower-contracting myofibers. The evolutionary mechanisms underlying this shift remain unclear. Here, we identify large MAF transcription factors (MAFA, MAFB, MAF) as key...

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Literature Corpus work
c3d8f028-d2d1-52b2-abfb-97a33f4c099f
DOI
10.1101/2024.12.09.627660
Open publication

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Large MAF Transcription Factors Reawaken Evolutionarily Dormant Fast-Glycolytic Type IIb Myofibers in Human Skeletal MuscleDOI 10.1101/2024.12.09.627660
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