Article
Continuous association of cadherin with beta-catenin requires the non-receptor tyrosine-kinase Fer.
Journal of cell science - 1 Jul 2004
Xu Gang, Craig Andrew W B, Greer Peter, Miller Matthew, Anastasiadis Panos Z, Lilien Jack, Balsamo Janne
Abstract excerpt
The function of Type 1, classic cadherins depends on their association with the actin cytoskeleton, a connection mediated by alpha- and beta-catenin. The phosphorylation state of beta-catenin is crucial for its association with cadherin and thus the association of cadherin with the cytoskeleton. We now show that the phosphorylation of beta-catenin is regulated by the combined activities of the tyrosine kinase Fer...
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