Article
Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells.
Molecular biology of the cell - 1 Sept 2003
Kogata Naoko, Masuda Michitaka, Kamioka Yuji, Yamagishi Akiko, Endo Akira, Okada Masato, Mochizuki Naoki
Abstract excerpt
Platelet endothelial adhesion molecule-1 (PECAM-1) is a part of intercellular junctions and triggers intracellular signaling cascades upon homophilic binding. The intracellular domain of PECAM-1 is tyrosine phosphorylated upon homophilic engagement. However, it remains unclear which tyrosine kinase phosphorylates PECAM-1. We sought to isolate tyrosine kinases responsible for PECAM-1 phosphorylation and identified...
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