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Article

Specific conserved C-terminal amino acids of Caenorhabditis elegans HMP-1/α-catenin modulate F-actin binding independently of vinculin.

The Journal of biological chemistry - 22 Feb 2013

Maiden Stephanie L, Harrison Neale, Keegan Jack, Cain Brian, Lynch Allison M, Pettitt Jonathan, Hardin Jeff

Abstract excerpt

Stable intercellular adhesions formed through the cadherin-catenin complex are important determinants of proper tissue architecture and help maintain tissue integrity during morphogenetic movements in developing embryos. A key regulator of this stability is α-catenin, which connects the cadherin-catenin complex to the actin cytoskeleton. Although the C-terminal F-actin-binding domain of α-catenin has been shown...

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PMID: 23271732
DOI: 10.1074/jbc.M112.438093
PMCID: PMC3581367

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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