Article
The Fes/Fer non-receptor tyrosine kinase cooperates with Src42A to regulate dorsal closure in Drosophila.
Development (Cambridge, England) - 1 Aug 2006
Murray Michael J, Davidson Catherine M, Hayward Neil M, Brand Andrea H
Abstract excerpt
Fes/Fer non-receptor tyrosine kinases regulate cell adhesion and cytoskeletal reorganisation through the modification of adherens junctions. Unregulated Fes/Fer kinase activity has been shown to lead to tumours in vivo. Here, we show that Drosophila Fer localises to adherens junctions in the dorsal epidermis and regulates a major morphological event, dorsal closure. Mutations in Src42A cause defects in dorsal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.