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Article

Autonomous replication of foreign DNA in Histoplasma capsulatum: role of native telomeric sequences

1 Feb 1993

Abstract excerpt

Genetic transformation of the dimorphic pathogenic fungus Histoplasma capsulatum can result in chromosomal integration of the transforming DNA or the generation of multicopy linear plasmids carrying the transforming DNA. We showed previously that Escherichia coli plasmids do not replicate autonomously in H. capsulatum without significant modifications, one of which is the in vivo addition of Histoplasma telomeres...

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Identifiers

PMID: 8423138
DOI: 10.1128/jb.175.3.636-641.1993

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