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RNA Interference-Mediated Silencing of theYPS3Gene ofHistoplasma capsulatumReveals Virulence Defects

3 Apr 2007

Abstract excerpt

The YPS3 gene of Histoplasma capsulatum encodes a protein that is both surface localized in the cell wall of H. capsulatum and released into the culture medium. This protein is produced only during the pathogenic yeast phase of infection and is also expressed differentially in H. capsulatum strains of different virulence levels. In this study, we silenced the YPS3 transcript by using an interfering-RNA strategy...

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PMID: 17403872
DOI: 10.1128/iai.00304-07

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