Article
TNR/11q#1 trinucleotide (GCC)n repeat alleles and predisposition to acute and chronic leukemia.
Annals of human genetics - 1 Jul 2004
Klinkov A A, Nikitin E A, Maiorova O V, Ivanov M A, Strelnikov V V, Babenko O V, Zemlyakova V V, Kuznetsova E B, Zaletayev D V
Abstract excerpt
TNR/11q#1 is a polymorphic trinucleotide (GCC)n repeat located within the minimal region of the 11q deletion in chronic lymphocytic leukemia (CLL). It was recently shown that certain alleles of this repeat are associated with a worse prognosis in CLL patients. To investigate the role of TNR/11q#1 variants as risk-modifying factors in leukemogenesis, we conducted a case-control study on 113 acute lymphotic...
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