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NF-κB1 -94del/del ATTG polymorphic variant maintains CLL at an early, mildest stage.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 May 2021

Urbanowicz Iwona, Wołowiec Dariusz, Wysoczańska Barbara, Łacina Piotr, Jonkisz Anna, Nahaczewska Wiesława, Tukiendorf Andrzej, Bil-Lula Iwona, Bogunia-Kubik Katarzyna, Pawlak Edyta

Abstract excerpt

BACKGROUND: NF-κB is an essential player in cancer biology, especially in tumor development, due to its constitutive activation, and because a four-base deletion (ATTG) in the NF-κB1 promoter region at site -94, alters mRNA stability and regulates translation efficiency. This polymorphism is a good candidate risk marker and modulator of clinical course in chronic lymphocytic leukemia (CLL). As the effect of this...

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PMID: 33982453
DOI: 10.17219/acem/128764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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