Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma.

doi:10.1097/00000478-200407000-00012

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Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma.

The American journal of surgical pathology - 1 Jul 2004

Nakatani Yukio, Miyagi Yohei, Takemura Tamiko, Oka Teruaki, Yokoi Toyoharu, Takagi Masayuki, Yokoyama Shigeo, Kashima Kenji, Hara Kazuo, Yamada Tetsuya, Nozawa Akinori, Inayama Yoshiaki, Sakamoto Kazuhiro, Ogawa Nobuo, Kitamura Hitoshi, Resl Milan, Cho Sang-Ho, Koss Michael N, Mark Eugene J

Abstract excerpt

It is now known that gene mutation of beta-catenin with subsequent nuclear/cytoplasmic (N/C) overaccumulation of the protein plays an important role in tumorigenesis of various organs. We recently demonstrated that low-grade adenocarcinoma of the fetal lung type (L-FLAC)/well-differentiated fetal adenocarcinoma (WDFA), the epithelial prototype of classic pulmonary blastoma (CPB), shows N/C localization of...

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Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma.

Abstract excerpt

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Aberrant nuclear/cytoplasmic localization and gene mutation of beta-catenin in classic pulmonary blastoma: beta-catenin immunostaining is useful for distinguishing between classic pulmonary blastoma and a blastomatoid variant of carcinosarcoma.

Abstract excerpt

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