Article
High-grade fetal adenocarcinoma of the lung is a tumour with a fetal phenotype that shows diverse differentiation, including high-grade neuroendocrine carcinoma: a clinicopathological, immunohistochemical and mutational study of 20 cases.
Histopathology - 1 Dec 2015
Suzuki Masaki, Yazawa Takuya, Ota Satoshi, Morimoto Junichi, Yoshino Ichiro, Yamanaka Shoji, Inayama Yoshiaki, Kawabata Yoshinori, Shimizu Yoshihiko, Komatsu Masayo, Notohara Kenji, Koda Kenji, Nakatani Yukio
Abstract excerpt
AIMS: High-grade fetal adenocarcinoma (H-FLAC) is a rare variant of pulmonary adenocarcinoma; this study aims to elucidate its clinicopathological features and genetic abnormalities. METHODS AND RESULTS: Clinicopathological, immunohistochemical and mutational analyses were performed on 20 surgically resected lung cancers that showed H-FLAC histology in various proportions. These tumours predominantly occurred in...
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