Article
Routine analysis of IgVH mutational status in CLL patients using BIOMED-2 standardized primers and protocols.
Leukemia & lymphoma - 1 Sept 2004
Matthews Christine, Catherwood Mark, Morris T C M 'Curly', Alexander H Denis
Abstract excerpt
Current methods for the detection of IgVH mutational status in chronic lymphocytic leukemia (CLL), which identifies 2 subgroups of patients with significantly different outcomes, are laborious, expensive and do not lend themselves to a routine diagnostic setting. With the introduction of BIOMED-2 primers, a rapid protocol is now available. This study evaluated the protocol by examining DNA from 100 CLL patients....
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