Article
Resting state conformation of the MsbA homodimer as studied by site-directed spin labeling.
Biochemistry - 6 Jul 2004
Buchaklian Adam H, Funk Andrea L, Klug Candice S
Abstract excerpt
MsbA is the ABC transporter for lipid A and is found in the inner membranes of Gram-negative bacteria such as Escherichia coli. Without MsbA present, bacterial cells accumulate a toxic amount of lipid A within their inner membranes. A crystal structure of MsbA was recently obtained that provides an excellent starting point for functional dynamics studies in membranes [Chang, and Roth (2001) Science 293,...
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