Article
Novel MC1R variants in Ligurian melanoma patients and controls.
Human mutation - 1 Jul 2004
Pastorino Lorenza, Cusano Roberto, Bruno William, Lantieri Francesca, Origone Paola, Barile Monica, Gliori Sara, Shepherd Graeme A, Sturm Richard A, Bianchi-Scarra Giovanna, Scarra Giovanna Bianchi
Abstract excerpt
Several variant forms of the melanocortin-1 receptor gene (MC1R) have been associated with red hair, fair skin and an increased risk for melanoma. Their involvement in melanoma susceptibility is apparently linked both to skin sensitivity and to non-pigmentary pathways. We investigated the frequency of the MC1R variants in the Italian region of Liguria, where the occurrence and penetrance of melanoma are low and...
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