Rapid multiplexed genotyping for hereditary thrombophilia by SELDI-TOF mass spectrometry.

Abstract excerpt

Approximately 50% of patients with venous thromboembolism also present with hereditary predisposition. The most common genetic factors are single nucleotide polymorphisms (SNPs) of factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T. Genotyping these SNPs helps clinicians to correctly diagnose the disease and properly manage patients. In this study, we report a novel method using...

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• Clinical Laboratory Techniques
• Factor V
• Mass Spectrometry
• Methylenetetrahydrofolate Reductase (NADPH2)
• Polymerase Chain Reaction