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Article

Novel indole-3-sulfonamides as potent HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs).

Bioorganic & medicinal chemistry letters - 15 Jan 2008

Zhao Zhijian, Wolkenberg Scott E, Sanderson Philip E J, Lu Meiqing, Munshi Vandna, Moyer Gregory, Feng Meizhen, Carella Anthony V, Ecto Linda T, Gabryelski Lori J, Lai Ming-Tain, Prasad Sridar G, Yan Youwei, McGaughey Georgia B, Miller Michael D, Lindsley Craig W, Hartman George D, Vacca Joseph P, Williams Theresa M

Abstract excerpt

This Letter describes the design, synthesis, and biological evaluation of novel 3-indole sulfonamides as potent non-nucleoside reverse transcriptase inhibitors (NNRTIs) with balanced profiles against common HIV RT mutants K103N and Y181C.

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Identifiers

PMID: 18083561
DOI: 10.1016/j.bmcl.2007.11.085

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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