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Article

Structure of pre-S2 N- and O-linked glycans in surface proteins from different genotypes of hepatitis B virus.

The Journal of general virology - 1 Jul 2004

Schmitt Sigrid, Glebe Dieter, Tolle Tanja K, Lochnit Günter, Linder Dietmar, Geyer Rudolf, Gerlich Wolfram H

Abstract excerpt

The middle-sized (M) surface proteins of hepatitis B virus (HBV) and other orthohepadnaviruses contain a conserved N-glycan in their pre-S2 domain, which is essential for the secretion of viral particles. Recently, we also found O-glycans in the pre-S2 domain of M protein from woodchuck hepatitis virus (WHV) and HBV genotype D. Since the O-glycosylation motif is not conserved in all genotypes of HBV, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15218190
DOI: 10.1099/vir.0.79932-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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