Article
Targeted therapy against human lung cancer in nude mice by high-affinity recombinant antimesothelin single-chain Fv immunotoxin.
Molecular cancer therapeutics - 1 Jun 2002
Fan Dominic, Yano Seiji, Shinohara Hisashi, Solorzano Carmen, Van Arsdall Melissa, Bucana Corazon D, Pathak Sen, Kruzel Ewa, Herbst Roy S, Onn Amir, Roach Jennifer S, Onda Masanori, Wang Qing-cheng, Pastan Ira, Fidler Isaiah J
Abstract excerpt
Several tumors, including mesothelioma and ovarian cancer, can overexpress mesothelin, a glycosylphosphatidylinositol-linked differentiation glycoprotein. The membrane-bound type of mesothelin is found in the blood of cancer patients at a very low level, which makes mesothelin a good candidate for targeted therapy of certain cancers. An antimesothelin disulfide-linked Fv (SS1 Fv) was fused to a truncated mutant...
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