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Article

Mesothelin Expression in Acute Leukemia: Correlations With Immunophenotype, Cytogenetics, and Mutational Status.

Applied immunohistochemistry & molecular morphology : AIMM - 1 May 2026

Ashour Dua'a N, Abbas Manal A, Sughayer Maher A

Abstract excerpt

Mesothelin is a surface glycoprotein overexpressed in several solid tumors and a known immunotherapy target. While present on blast cells in acute myeloid leukemia (AML), its role in acute lymphoblastic leukemia (ALL) remains unclear. This study evaluated mesothelin expression in 181 newly diagnosed acute leukemia cases using immunohistochemistry (IHC) on bone marrow biopsies and ELISA on plasma samples....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41629741
DOI: 10.1097/PAI.0000000000001302
PMCID: PMC13143374

Genes

CD38
DNMT3A
GATA2
NPM1
CBLC
CD33
KDM6A
KMT2A
PHF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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