Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of the mouse Jhy gene causes abnormal ciliary microtubule patterning and juvenile hydrocephalus.

Developmental biology - 1 Oct 2013

Appelbe Oliver K, Bollman Bryan, Attarwala Ali, Triebes Lindy A, Muniz-Talavera Hilmarie, Curry Daniel J, Schmidt Jennifer V

Abstract excerpt

Congenital hydrocephalus, the accumulation of excess cerebrospinal fluid (CSF) in the ventricles of the brain, affects one of every 1000 children born today, making it one of the most common human developmental disorders. Genetic causes of hydrocephalus are poorly understood in humans, but animal models suggest a broad genetic program underlying the regulation of CSF balance. In this study, the random integration...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebrospinal Fluid
Share to Cilia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Genes, Reporter

Share to Hydrocephalus

Share to Microtubules

Share to Syndrome

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 23906841
DOI: 10.1016/j.ydbio.2013.07.003
PMCID: PMC3783533

Genes

JHY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of the mouse Jhy gene causes abnormal ciliary microtubule patterning and juvenile hydrocephalus.PMID 23906841Read ↗

Genetics and Molecular Pathogenesis of Human HydrocephalusSemantic proximity Read ↗

A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in miceSemantic proximity Read ↗

Congenital hydrocephalus in genetically engineered mice.Semantic proximity Read ↗

Congenital hydrocephalus in hy3 mice is caused by a frameshift mutation in Hydin, a large novel geneSemantic proximity Read ↗

Riding the wave of ependymal cilia: genetic susceptibility to hydrocephalus in primary ciliary dyskinesia.Semantic proximity Read ↗

Heterozygous FOXJ1 Mutations Cause Incomplete Ependymal Cell Differentiation and Communicating Hydrocephalus.Semantic proximity Read ↗

Congenital hydrocephalus: a review of recent advances in genetic etiology and molecular mechanisms.Semantic proximity Read ↗

Hydrocephalus in Connection to Genetic Mutation in Cranial Neural Crest Cells.Semantic proximity Read ↗

Identification of disease-relevant modulators of the SHH pathway in the developing brain.Semantic proximity Read ↗

Mutations in <i>Kinesin Family Member 6</i> Reveal Specific Role in Ependymal Cell Function and Human Neuro-Cranial DevelopmentSemantic proximity Read ↗

Loss of Dynein Axonemal Heavy Chain 5 Causes Cortical Development Disorders and CSF Flow StagnationSemantic proximity Read ↗

Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch/Mf1) arise from a winged helix/forkhead transcriptionfactor gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.