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Article

Local adaptation and population differentiation at the interleukin 13 and interleukin 4 loci.

Genes and immunity - 1 Aug 2004

Sakagami T, Witherspoon D J, Nakajima T, Jinnai N, Wooding S, Jorde L B, Hasegawa T, Suzuki E, Gejyo F, Inoue I

Abstract excerpt

A 25.6 kb region at chromosome 5q31, covering the entire human interleukin 13 (IL-13) and interleukin 4 (IL-4) genes, has been reported to be associated with bronchial asthma. We have examined nucleotide variations at this locus in African, European American, and Japanese populations, using 120 diallelic variants. A block of strong linkage disequilibrium (LD) (mid R:D'mid R:>0.7) spans a 10 kb region containing...

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PMID: 15215888
DOI: 10.1038/sj.gene.6364109

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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