Article
The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.
Archives of biochemistry and biophysics - 1 Jan 2000
Klinge C M, Kaur K, Swanson H I
Abstract excerpt
The molecular mechanisms underlying the apparent "cross-talk" between estrogen receptor (ER)- and arylhydrocarbon receptor (AHR)-mediated activities are unknown. To determine how AHR ligand 2, 3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) may inhibit ER action and, conversely, to examine how 17-beta-estradiol (E(2)) affects AHR activity, we examined discrete activities of each receptor, i.e., protein-protein...
Topics
- Amino Acid Sequence
- Animals
- Aryl Hydrocarbon Receptor Nuclear Translocator
- Base Sequence
- Binding Sites
- COUP Transcription Factor I
- Cell Line
- Cytochrome P-450 CYP1A1
- DNA Primers
- DNA-Binding Proteins
- Estradiol
- Estrogen Receptor alpha
- Gene Expression