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Article

Analysis of polymorphic TGFB1 codons 10, 25, and 263 in a German patient group with non-syndromic cleft lip, alveolus, and palate compared with healthy adults.

BMC medical genetics - 22 Jun 2004

Stoll Christian, Mengsteab Senait, Stoll Doris, Riediger Dieter, Gressner Axel M, Weiskirchen Ralf

Abstract excerpt

BACKGROUND: Clefts of the lip, alveolus, and palate (CLPs) rank among the most frequent and significant congenital malformations. Leu10Pro and Arg25Pro polymorphisms in the precursor region and Thr263Ile polymorphism in the prodomain of the transforming growth factor beta1 (TGF-beta1) gene have proved to be crucial to predisposition of several disorders. METHODS: In this study, polymorphism analysis was performed...

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Source

Open in PubMed Open full text

Identifiers

PMID: 15212689
DOI: 10.1186/1471-2350-5-15
PMCID: PMC441379

Genes

TGFB1

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Source receipt: pubmed, retrieved 7 Sept 2026.

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