Transforming growth factor-beta receptor type 1 (TGFBR1) is not associated with non-syndromic cleft lip with or without cleft palate in patients of Central European descent.

doi:10.1016/j.ijporl.2009.06.004

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Article

Transforming growth factor-beta receptor type 1 (TGFBR1) is not associated with non-syndromic cleft lip with or without cleft palate in patients of Central European descent.

International journal of pediatric otorhinolaryngology - 1 Oct 2009

Reutter Heiko, Birnbaum Stefanie, Mende Meinhard, de Assis Nilma Almeida, Hoffmann Per, Lacava Amalia Diaz, Herms Stefan, Braumann Bert, Scheer Martin, Lauster Carola, Schmidt Gül, Schiefke Franziska, Dunsche Anton, Martini Markus, Knapp Michael, Kramer Franz-Josef, Nöthen Markus M, Mangold Elisabeth

Abstract excerpt

OBJECTIVE: Transforming growth factor-beta (TGF-β) type 1 receptor (also known as activin receptor-like kinase 5, ALK5) is expressed in palatal tissue during embryogenesis. Experimental studies in transgenic mice with a genetic deletion of Alk5 showed that TGF-β type 1 receptor is required for upper lip and midline fusion of the hard and soft palate. In humans, association of TGF-β type 1 receptor gene (TGFBR1)...

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PMID: 19586667
DOI: 10.1016/j.ijporl.2009.06.004

Genes

TGFBR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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