Article
Genetic polymorphisms of TGF-beta, PAI-1, and COL1A-1, and determination of bone mineral density in Caucasian females.
Endocrine regulations - 1 Sept 2006
Hubacek Jaroslav A, Weichetova Marketa, Bohuslavova Romana, Skodova Zdena, Adámkova Vera, Stepan Jan J
Abstract excerpt
OBJECTIVE: The aim of this study was to examine whether the variants in genes for transforming growth factor beta1 (TGF-beta1; Leu10>Pro and Arg25>Pro), plasminogen activator inhibitor 1 (PAI-1; 4G>5G variant) and collagen -1 (COL1A-1; Sp1 variant) may be useful in identifying individuals with increased susceptibility to early postmenopausal bone loss within the population of Czech women. METHODS: Polymorphisms...
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