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Article

A common ABCC2 promoter polymorphism is not a determinant of the risk of spina bifida.

Birth defects research. Part A, Clinical and molecular teratology - 1 Jun 2004

Jensen Liselotte E, Wall Amelia M, Cook Michelle, Hoess Katy, Thorn Caroline F, Whitehead Alexander S, Mitchell Laura E

Abstract excerpt

BACKGROUND: There is compelling evidence that the risk of spina bifida, a malformation of the caudal neural tube, is associated with maternal and/or embryonic disturbances in folate/homocysteine metabolism. Hence, functional variants of genes that influence folate/homocysteine metabolism constitute a biologically plausible group of candidate risk factors for spina bifida and other neural tube defects. One such...

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Share to ATP-Binding Cassette Transporters
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15211708
DOI: 10.1002/bdra.20023

Genes

ABCC2

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A common ABCC2 promoter polymorphism is not a determinant of the risk of spina bifida.PMID 15211708Read ↗

Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts?Semantic proximity Read ↗

118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.Semantic proximity Read ↗

Spina bifida as a multifactorial birth defect: Risk factors and genetic underpinningsSemantic proximity Read ↗

Nicotinamide N-methyl transferase (NNMT) gene polymorphisms and risk for spina bifida.Semantic proximity Read ↗

The C677T mutation of the 5,10-methylenetetrahydrofolate reductase gene is a moderate risk factor for spina bifida in Italy.Semantic proximity Read ↗

Evaluation of 64 candidate single nucleotide polymorphisms as risk factors for neural tube defects in a large Irish study population.Semantic proximity Read ↗

Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida.Semantic proximity Read ↗

Evidence that the risk of spina bifida is influenced by genetic variation at the NOS3 locus.Semantic proximity Read ↗

An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).Semantic proximity Read ↗

Heme oxygenase-1 promoter polymorphisms and risk of spina bifida.Semantic proximity Read ↗

Spina bifida and folate-related genes: a study of gene-gene interactions.Semantic proximity Read ↗

Maternal genetic effects, exerted by genes involved in homocysteine remethylation, influence the risk of spina bifida.Semantic proximity Read ↗

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