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Article

Protein tyrosine phosphatase non-receptor 22 and C-Src tyrosine kinase genes are down-regulated in patients with rheumatoid arthritis.

Scientific reports - 5 Sept 2017

Remuzgo-Martínez Sara, Genre Fernanda, Castañeda Santos, Corrales Alfonso, Moreno-Fresneda Pablo, Ubilla Begoña, Mijares Verónica, Portilla Virginia, González-Vela Jesús, Pina Trinitario, Ocejo-Vinyals Gonzalo, Irure-Ventura Juan, Blanco Ricardo, Martín Javier, Llorca Javier, López-Mejías Raquel, González-Gay Miguel A

Abstract excerpt

Several protein tyrosine phosphatase non-receptor 22 (PTPN22) single-nucleotide polymorphisms (SNPs) have been significantly related with rheumatoid arthritis (RA) susceptibility. Nevertheless, its potential influence on PTPN22 expression in RA has not been completely elucidated. Furthermore, PTPN22 binds to C-Src tyrosine kinase (CSK) forming a key complex in autoimmunity. However, the information of CSK gene in...

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Source

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Identifiers

PMID: 28874816
DOI: 10.1038/s41598-017-10915-9
PMCID: PMC5585411

Genes

PTPN22
CSK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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