Article
BCR/ABL rearrangement with b3a3 fusion transcript in a case of childhood acute lymphoblastic leukemia.
Cancer genetics and cytogenetics - 1 Mar 2009
Kim Juwon, Park Tae Sung, Lyu Chuhl Joo, Song Jaewoo, Lee Kyung-A, Kim Sue Jung, Lee Hyeon-Ji, Choi Jong Rak
Abstract excerpt
The role of BCR/ABL isoforms and their relationship to leukemia phenotype have been of major concern. Atypical BCR/ABL mRNA transcripts lacking exon a2 have been reported in 12 cases of acute lymphoblastic leukemia (ALL) to date; among them, a b3a3 type transcript has been reported only once in the childhood ALL. Reported here is the case of a patient with Philadelphia-positive (Ph(+)) ALL expressing a b3a3 type...
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