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Article

A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone.

Nature genetics - 1 Jul 2004

Dos Santos Christine, Essioux Laurent, Teinturier Cécile, Tauber Maïté, Goffin Vincent, Bougnères Pierre

Abstract excerpt

Growth hormone is used to increase height in short children who are not deficient in growth hormone, but its efficacy varies largely across individuals. The genetic factors responsible for this variation are entirely unknown. In two cohorts of short children treated with growth hormone, we found that an isoform of the growth hormone receptor gene that lacks exon 3 (d3-GHR) was associated with 1.7 to 2 times more...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 15208626
DOI: 10.1038/ng1379

Genes

GHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A common polymorphism of the growth hormone receptor is associated with increased responsiveness to growth hormone.PMID 15208626Read ↗

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