Article
Determination of an RNA structure involved in splicing inhibition of a muscle-specific exon.
Journal of molecular biology - 5 Oct 1991
Clouet d'Orval B, d'Aubenton-Carafa Y, Brody J M, Brody E
Abstract excerpt
We have investigated the RNA structure of the region surrounding the muscle-specific exon 6B of the chicken beta-tropomyosin gene. We have used a variety of chemical and enzymatic probes: dimethylsulfate, N-cyclohexyl-N'-(2-(N-methylmorpholino)-ethyl)-carbodiimide-p-tolu enesulfonate) , RNase T1 and RNase V1. Lead acetate was also used to obtain some information on the tertiary structure of this region. Probing...
Topics
- Animals
- Base Sequence
- Chickens
- DNA
- Exons
- Models, Chemical
- Molecular Sequence Data
- Muscles
- Mutation
- Nucleic Acid Conformation
- Organometallic Compounds
- RNA Precursors
