Article
Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo.
RNA (New York, N.Y.) - 1 Jul 1997
Pérez I, Lin C H, McAfee J G, Patton J G
Abstract excerpt
Alternative splicing of pre-mRNA is a commonly used mechanism to regulate gene expression in higher eukaryotes. However, with the exception of regulated cascades in Drosophila, the cis-acting elements and the trans-acting factors that control tissue- and/or developmentally regulated splicing rema...
Topics
- Alternative Splicing
- Animals
- Base Sequence
- Binding Sites
- Cells, Cultured
- Cross-Linking Reagents
- Exons
- Humans
- Molecular Sequence Data
- Muscle, Smooth
- Mutation
- Nuclear Proteins
- Polypyrimidine Tract-Binding Protein
- RNA
- RNA-Binding Proteins
- Recombinant Proteins
- Regulatory Sequences, Nucleic Acid
- Ribonucleoproteins