Article
p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.
Molecular and cellular neurosciences - 1 Jun 2004
Ackerley Steven, Grierson Andrew J, Banner Steven, Perkinton Michael S, Brownlees Janet, Byers Helen L, Ward Malcolm, Thornhill Paul, Hussain Kader, Waby Jennifer S, Anderton Brian H, Cooper Jonathan D, Dingwall Colin, Leigh P Nigel, Shaw Christopher E, Miller Christopher C J
Abstract excerpt
Neurofilament middle and heavy chains (NFM and NFH) are heavily phosphorylated on their carboxy-terminal side-arm domains in axons. The mechanisms that regulate this phosphorylation are complex. Here, we demonstrate that p38alpha, a member of the stress-activated protein kinase family, will phosphorylate NFM and NFH on their side-arm domains. Aberrant accumulations of neurofilaments containing phosphorylated NFM...
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