Article
Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis.
Human molecular genetics - 1 Feb 1999
Al-Chalabi A, Andersen P M, Nilsson P, Chioza B, Andersson J L, Russ C, Shaw C E, Powell J F, Leigh P N
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degeneration resulting in paralysis and death, usually within 3 years of onset. Pathological and animal studies implicate neurofilament involvement in ALS, but whether this is primary or secondary is not clear. The heavy neurofilam...
Topics
- Adult
- Aged
- Alleles
- Amyotrophic Lateral Sclerosis
- Base Sequence
- DNA
- Female
- Gene Frequency
- Genotype
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Neurofilament Proteins
- Pedigree
- Point Mutation
- Polymorphism, Restriction Fragment Length
- Polymorphism, Single-Stranded Conformational