Article
Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis.
Human molecular genetics - 1 Feb 1999
Al-Chalabi A, Andersen P M, Nilsson P, Chioza B, Andersson J L, Russ C, Shaw C E, Powell J F, Leigh P N
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degeneration resulting in paralysis and death, usually within 3 years of onset. Pathological and animal studies implicate neurofilament involvement in ALS, but whether this is primary or secondary is not clear. The heavy neurofilament subunit (NFH) tail is composed of a repeating amino acid motif, usually X-lysine-serine-proline-Y-lysine (XKSPYK),...
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