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Article

beta-Amyloid peptide induces formation of actin stress fibers through p38 mitogen-activated protein kinase.

Journal of neurochemistry - 1 Nov 2002

Song Cheng, Perides George, Wang Dechun, Liu Ya Fang

Abstract excerpt

Based on the critical role of actin in the maintenance of synaptic function, we examined whether expression of familial beta-amyloid precursor protein APP-V642I (IAPP) or mutant presenilin-1 L286V (mPS1) affects actin polymerization in rat septal neuronal cells. Expression of either IAPP or mPS1 but not wild-type amyloid precursor protein or presenilin-1induced formation of actin stress fibers in SN1 cells, a...

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Source

Identifiers

PMID: 12421354
DOI: 10.1046/j.1471-4159.2002.01182.x

Genes

IAPP
APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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