Article
Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis.
Human molecular genetics - 1 Oct 1994
Figlewicz D A, Krizus A, Martinoli M G, Meininger V, Dib M, Rouleau G A, Julien J P
Abstract excerpt
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder primarily affecting motor neurons. The etiology of the majority of cases remains unknown. Recent findings from several laboratories suggest a role for neurofilaments in the development of motor neuron disorders. The C-terminal re...
Topics
- Aged
- Amino Acid Sequence
- Amyotrophic Lateral Sclerosis
- Base Sequence
- Cloning, Molecular
- DNA
- DNA Primers
- Female
- Genetic Variation
- Humans
- Macromolecular Substances
- Male
- Middle Aged
- Molecular Sequence Data
- Neurofilament Proteins
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid