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Article

Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis.

Human molecular genetics - 1 Oct 1994

Figlewicz D A, Krizus A, Martinoli M G, Meininger V, Dib M, Rouleau G A, Julien J P

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder primarily affecting motor neurons. The etiology of the majority of cases remains unknown. Recent findings from several laboratories suggest a role for neurofilaments in the development of motor neuron disorders. The C-terminal region of the human neurofilament heavy subunit (NEFH) contains a unique functional domain consisting of 43 repeat motifs...

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Source

Identifiers

PMID: 7849698
DOI: 10.1093/hmg/3.10.1757

Genes

NEFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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