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Genetic and phenotypic characterization of tumor cells derived from malignant peripheral nerve sheath tumors of neurofibromatosis type 1 patients.

Neurobiology of disease - 1 Jun 2004

Frahm Silke, Mautner Victor-F, Brems Hilde, Legius Eric, Debiec-Rychter Maria, Friedrich Reinhard E, Knöfel Wolfram T, Peiper Matthias, Kluwe Lan

Abstract excerpt

Neurofibromatosis type 1 (NF1) patients have an 8-13% lifetime risk of developing malignant peripheral nerve sheath tumors (MPNST) which have a very poor prognosis. In this study, cells from eight MPNSTs (six primary and two recurrences) of six clinically and genetically well-characterized NF1 patients were taken into culture. Tracing of loss of heterozygosity (LOH) of the NF1, p53, and p16 gene regions or of...

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Identifiers

PMID: 15207265
DOI: 10.1016/j.nbd.2004.01.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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