Article
Neurogenin1 is sufficient to induce neuronal differentiation of embryonal carcinoma P19 cells in the absence of retinoic acid.
Cellular and molecular neurobiology - 1 Jun 2004
Kim Soyeon, Yoon Yong-Soo, Kim Ji-Won, Jung Miyoung, Kim Seung-Up, Lee Young-Don, Suh-Kim Haeyoung
Abstract excerpt
1. Neurogenin1 (Ngn1) is a basic helix-loop-helix (bHLH) transcription factor that is expressed in neuronal precursors during development of the nervous system. 2. In the present work, we investigated a instructive potential of Ngn1 in pluripotent embryonal carcinoma P19 cells. Treatment with retinoic acid (RA) induced expression of Ngn1 as well as NeuroD in P19 cells in early period of neuronal differentiation....
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