Article
Cigarette smoking has a differential effect on the plasma level of clozapine in Taiwanese schizophrenic patients associated with the CYP1A2 gene -163A/C single nucleotide polymorphism.
Psychiatric genetics - 1 Aug 2016
Huang Hui-Ching, Lua Ahai Chang, Wu Lawrence Shih-Hsin, Wu Bo-Jian, Lee Shin-Min, Liu Chao-Zong
Abstract excerpt
OBJECTIVE: The efficacy of clozapine clearance has been shown to be associated with smoking and genetic polymorphism of CYP1A2. This study aims to investigate the effect of smoking on the plasma level of clozapine in Taiwanese schizophrenic patients and its relevance to the CYP1A2 gene -163A/C single nucleotide polymorphism. MATERIALS AND METHODS: A total of 143 hospitalized schizophrenic patients who had...
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