Article
Metabolic polymorphisms, smoking, and oral cancer in Puerto Rico.
Oncology research - 1 Jan 2004
Xie Heng, Hou Lifang, Shields Peter G, Winn Deborah M, Gridley Gloria, Bravo-Otero Eleuterio, Diehl Scott R, Bowman Elise D, Brown Linda M, Hayes Richard B
Abstract excerpt
Genetic polymorphisms resulting in variation in metabolism of tobacco carcinogens may influence oral cancer risk. In a population-based case-control study in Puerto Rico, genotypes of CYP1A1, GSTM1, and GSTT1 were determined by a PCR-based method for 132 oral cancer patients and 143 control subjects. Genotype-associated risks were estimated by logistic regression. The null variant of GSTM1 was associated with a...
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