Article
Body mass index but not a polymorphism of the interleukin-1 receptor antagonist (IL-1 RA) gene is associated with age at natural menopause.
Gynecologic and obstetric investigation - 1 Jan 2004
Riener Eva-Katrin, Keck Christoph, Worda Christof, Hefler Lukas A, Tempfer Clemens B
Abstract excerpt
BACKGROUND: A genetic component of the onset of menopause has been described and several candidate genes have been identified. We hypothesized that carriage of a polymorphism of the interleukin-1 receptor antagonist gene (IL-1 RA) is associated with an early age at menopause. METHODS: In a prospective cohort study, 90 consecutive postmenopausal Caucasian women were genotyped by PCR for the presence of an 86-base...
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